AB Biotek Improves DAO Delivery with Microencapsulation

Monday, April 8th, 2024

AB Biotek Human Nutrition and Health (HNH) has launched adiDAO microencapsulated, a new ingredient format that optimises the delivery of the DAO enzyme and allows it to be combined with other functional ingredients for the first time.

DAO (diamine oxidase) helps the body to break down dietary histamine, a molecule that is naturally present in all food types but is found in particularly high concentrations in fish, dairy products, cheese, and wine.

Increased levels of unmetabolized histamine in the bloodstream may result in gastro-intestinal issues, skin conditions, lower urinary tract (LUTS) symptoms, fibromyalgia, migraine and attention deficit hyperactivity disorder (ADHD). DAO deficiency is one of the world’s most common enzyme-related metabolic disorders.

There is growing interest in solutions that enhance histamine degradation by increasing levels of DAO in the gut. However, DAO is sensitive to stomach pH, necessitating the use of delivery mechanisms that are gastro-resistant. In addition, DAO tends to interact with other bioactive ingredients in a way that diminishes its benefits.

AB Biotek HNH’s latest innovation offers a unique solution to both challenges. In adiDAO microencapsulated, the DAO is surrounded by two food-grade protective layers produced using a combination of coating technologies. These layers are specially designed to protect the DAO, optimising its delivery when it reaches the small intestine. The layers also help to prevent undesirable interactions with other bioactive ingredients.

The technology creates new opportunities for developing innovative products in both the pharmaceutical and nutraceutical spaces. For example, it will enable manufacturers to include DAO in anti-histamine and ADHD treatments, or to combine it with probiotics or prebiotics in supplements.

Compatible with various pharmaceutical actives in different concentrations, adiDAO microencapsulated can be used to create bespoke, targeted solutions, offering convenience and improving patient compliance. Other benefits include a simplified production process and reduced manufacturing costs versus traditional gastro-resistance coating methods.